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deskgameThe Crimson Tide and Wolverines will square off in the ReliaQuest Bowl in Tampa, Fla., at noon ET. Alabama is a lofty 14- or 14.5-point favorite. The over/under is 43.5 points. deskgameMahomes has passed for 260+ yards in each of his last three games. He has passed for 15 TDs in seven career starts against the Bills. Mahomes will get JuJu Smith-Schuster back from a hamstring injury this week to pair with new top WR DeAndre Hopkins. deskgameNFL Profit Boosts: Enjoy weekly odds boosts and profit boosts on all Week 17 NFL matchups. deskgameThe offenses are mainly intact. However, Michigan will miss RB Donovan Edwards. That will affect how Michigan runs an offense that averaged an underwhelming 22 points per game.